|
|
|
|
|
Click Here to return To Results
|
|
|
|
Three previously healthy immunocompetent gay men in their 30s developed a febrile illness followed by progressive neurologic symptoms with presence of a vesiculopustular rash. MPXV nucleic acid was detected by polymerase chain reaction (PCR) from skin lesions of 2 patients, with the third patient having indeterminate testing but an epidemiologic link to a confirmed MPXV-specific PCR. In 2 patients, magnetic resonance imaging of the brain and spine demonstrated partially enhancing longitudinally extensive central spinal cord lesions with multifocal subcortical, basal ganglia, thalamic, cerebellar, and/or brainstem lesions. The third patient had thalamic and basal ganglia lesions. All patients received 14 days of tecovirimat, and 2 patients also received multiple forms of immunotherapy, including intravenous immunoglobulin, pulsed high-dose steroids, plasmapheresis, and/or rituximab. Good neurologic recovery was observed in all cases. MPXV can be associated with CNS disease. It is unclear whether this is from a parainfectious immune-mediated injury or direct CNS viral invasion. |
|
(click to filter results - removes previous filter)
basal ganglia,lesion,bilateral
brainstem,lesion of
central nervous system,infection of
cerebellar lesion
deep gray nuclei
encephalitis
encephalopathy
fever
headache
homosexual
immunotherapy
Monkeypox infection
MRI,abnormal
MRI,contrast enhanced
MRI,spinal cord
myelitis,longitudinal
neurologic disease,diagnoses of
pleocytosis of cerebrospinal fluid
polymerase chain reaction
prevention of neurologic disorders
rash
review article
thalamus,lesion of-bilateral
treatment of neurologic disorder
vaccine
viral infection
viral infection,CNS
white matter disease
|
Click Here to return To Results
|
|